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Dr. Steven Mandel & Sam Mandel: The Efficacy of Ketamine Infusion Therapy

April 2, 2021

A hot topic in the world of psychedelic medicine is whether ketamine infusion therapy is as effective as ketamine-assisted therapy. Today’s guests Dr. Steven Mandel and his son Sam Mandel have administered over 13,000 intravenous treatments.

On the show we discuss the efficacy of IV ketamine therapy and how it compares to intramuscular as a route of administration. We talk about Dr. Mandel’s specific protocol including the use of a pump instead of a drip bag for administration. We cover the potential health concerns around ketamine and finish as always with advice to psychedelic therapists.

Dr. Steven Mandel has more than 40 years of experience utilizing ketamine as a board-certified anesthesiologist and has a master’s degree in psychology. He is the co-founder and president of Ketamine Clinics Los Angeles, and the co-founder of American Society of Ketamine Physicians, Psychotherapists and Practitioners.

Sam Mandel is co-founder and chief operating officer of Ketamine Clinics Los Angeles. A mental health advocate and entrepreneur, he oversees all non-clinical functions of the company and has been active in the ketamine infusion therapy community since its formative days.

Show notes



  • :05 - How Dr. Mendel and his son Sam started the Ketamine Clinics of Los Angeles
  • :09 - Should psychedelic practitioners receive the treatment themselves?
  • :16 - How ketamine functions in the brain
  • :23 - Is ketamine infusion therapy as effective as psychedelic-assisted talk therapy?
  • :32 - Intravenous vs Intramuscular ketamine
  • :39 - Dr. Mandel’s ketamine protocol
  • :46 - How do you assess the effectiveness of ketamine therapy?
  • :54 - Potential issues with ketamine use: addiction, bladder damage, or cognitive impairment.
  • 1:08 - Dr. Steven and Sam Mandel share their advice
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About Maya’s Podcast

A conversation series with leaders in the psychedelic community. Designed in service of therapists, healers, retreat leaders, and passionate enthusiasts

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